ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline nor with disease progression
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چکیده
ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline nor with disease progression Arthritis Research & Therapy 2013, 15:R140 doi:10.1186/ar4322 Joyce JBC van Beers ([email protected]) Annemiek Willemze ([email protected]) Jeroen J Jansen ([email protected]) Gerard HM Engbers ([email protected]) Martin Salden ([email protected]) Jos Raats ([email protected]) Jan W Drijfhout ([email protected]) Annette HM van der Helm-van Mil ([email protected]) Rene EM Toes ([email protected]) Ger JM Pruijn ([email protected])
منابع مشابه
ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression
INTRODUCTION Autoantibodies against citrullinated peptides/proteins (ACPA) are found in approximately 75% of the sera of patients with rheumatoid arthritis (RA). The RA-specific ACPA are frequently present prior to disease onset and their presence associates with a more erosive disease course. ACPA can therefore be used to aid the diagnosis and prognosis of RA. Recently, it became clear that AC...
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Anti-cyclic peptide antibodies (CCP/ACPA) are directed towards synthetic citrullinated peptides and are specific markers in diagnosis of Rheumatoid arthritis. This study aimed to compare the values and acuracy of the test in anticyclic citrullinated peptides (Anti-CCP /ACPA) antibodies, rheumatoid factor (RF), C-reactive protein (CRP) and disease activity index (PASI) in early diagnosis of untr...
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The introduction of tests recognizing 'anti-citrullinated protein antibodies' (ACPA) has caused a revolution in rheumatology. Immunization against citrullinated proteins is a feature almost unique for rheumatoid arthritis, although ACPA may occur long before the onset of symptoms. Even if the presence of ACPA does not seem to reveal a distinct arthritis phenotype at symptom onset, it predicts a...
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A number of patients with inflammatory arthritis due to inadequate clinical or laboratory data do not fulfill diagnostic criteria for a clinical disease categories. These patients with initial diagnosis of undifferentiated arthritis (UA) may remit or progress to a definite well- defined condition such as rheumatoid arthritis (RA) or remain as UA with persistence of inflammatory arthritis. The m...
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OBJECTIVES Human leucocyte antigen shared epitope (SE) alleles are associated with joint destruction, the presence of anticitrullinated protein antibodies (ACPA) and the ACPA fine specificity repertoire in rheumatoid arthritis (RA). A large variation in joint destruction is seen within the ACPA-positive patient population, and it is conceivable that certain ACPA reactivities contribute to radio...
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